What You Need to Know About Fat Digestion and Digestive Enzymes - Specialty Enzymes & Probiotics™ (2023)

What You Need to Know About Fat Digestion and Digestive Enzymes

June 27, 2019

Digestive Enzymes

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Carbohydrates, proteins, vitamins, minerals and water. What’s missing from this list of essential nutrients? Fats! An essential nutrient is one the body needs to function normally. However, the human body can’t make essential nutrients by itself. If you want to keep on keepin’ on, you must feed your body the fuel it needs to survive. Unfortunately, there are lots of illnesses that make it difficult or impossible for your body to digest these nutrients.This can cause malabsorption and malnourishment. Some of these are short-term problems that can be treated, while others are chronic conditions that need to be monitored throughout your life. In this overview, we’re going to take a look at both short- and long-term health issues that impact the way your body digests and uses the fats it needs to keep you working, living and enjoying life to the best of your ability. Plus, we’ll dig deeper into what you can do today to improve your fat digestion in order to stay happy and healthy.

Why Fat Digestion Is Important

Before we dig into what causes fat digestion problems, we need to understand why fats are so essential to your body’s most basic functions. After all, fats get a bad rap, but we can’t live without them. Why is that?

What You Need to Know About Fat Digestion and Digestive Enzymes - Specialty Enzymes & Probiotics™ (1)Dietary fats, which are also called lipids, do a few different things. Primarily,your body uses them as an energy source. Short bursts of energy tend to come from burning carbohydrates. For more long-term energy, your body then begins burning fat. If your body can’t digest fat, you’re losing an energy source. You’ll find that your endurance flags and you become fatigued more easily. But that’s not all fats do. Like many other nutrients, they’re multi-taskers. Besides being an energy source, dietary fats contain essential fatty acids that humans cannot synthesize but are needed by the body to make molecules needed by the body to function properly. Also, dietary fats contain omega-3 fatty acids that have been shown to have benefits from reducing serum cholesterol to decreasing inflammation. So the proper digestion of dietary fats to obtain the essential fatty acids and omega-3 fatty acids is essential for good health. Fats keep your hair, skin and nails strong and supple. There are vitamins, including A, D, E and K, that are stored in your body’s fat cells. There are fatty acids that your body needs to take care of a variety of different activities, like clotting your blood and decreasing inflammation. They’re also an important building block in your brain. Did you know that 60 percent ofyour brain is made up of fat? It’s true! Your brain relies on fat to function. If your body isn’t absorbing fat properly, that will affect the way you think. It could also impact your future. Fat cells help protect the brain against debilitating diseases like Alzheimer’s and dementia. On top of all that, layers of fat around your body keep you warm and cushion your skeletal system and your organs. Just like the other essential micronutrients and macronutrients, fats are present all over your body. They are in your hair follicles and your fingertips, your brain and your biceps. They are necessary for innumerable processes that help you think, help you stand and help you go about your day, no matter what the day may bring your way.

Medical Conditions That Affect Fat Digestion

There are all sorts of illnesses that can influence the way your body digests nutrients. Here’s a shortlist of conditions most likely to prevent you from absorbing the fats you need for whole-body health from head to toe:


A parasite is a type of organism that lives off a host, drawing nutrients from the host’s body and often depriving the host of the essentials it needs to survive and thrive. There are lots of different kinds of parasites that set up shop in the intestines and can cause malabsorption, including worms, spores and blastocysts. A stool sample can be used todiagnose a parasitic infection.

Inflammatory bowel diseases

IBD is an umbrella term for Crohn’s disease, ulcerative colitis and irritable bowel syndrome—all of which are chronic diseases that affect the large and small intestines. The longer the trio goes untreated, the more damage they can do to the lining of your intestines, which is what allows you to absorb essential nutrients. A GI doctor will be able to diagnose you through symptom assessment, blood tests and an endoscopy or colonoscopy.

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Cystic fibrosis

Cystic fibrosis is well-known for devastating the respiratory system, but it can also impact other body systems as well, including the GI tract. CF affects the way salt and water move in and out of cells, creating lots of mucus. The pancreas, which secretes the digestive enzyme lipase that breaks down fat, is overwhelmed by mucus. That means manypeople with cystic fibrosis struggle to absorb fatsas well as fat-soluble vitamins.

Food intolerances and sensitivities

An intolerance or a sensitivity to certain foods is often caused by the body not producing the digestive enzyme that breaks down a certain nutrient. In the case of lactose intolerance, the body doesn’t create enough lactase, which is an enzyme that breaks down milk sugar into simpler carbohydrates.

Celiac disease

There are wheat and gluten sensitivities, and then there is celiac disease. Celiac is an autoimmune disease like rheumatoid arthritis, which means that the immune system attacks a part of the body when a trigger is present. In the case of celiac disease, the immune system damages the small intestine when gluten is ingested. If the damage continues, the small intestine can’t absorb nutrients, including fats, which can lead to malnutrition in addition to other GI symptoms.

Chronic pancreatitis

Inflammation of the pancreas can be a one-off illness, or acute, as well as a continual condition that gets progressively worse, or chronic. Chronic pancreatitis slowly destroys the pancreas and inhibits its ability to produce digestive enzymes, including lipase. Nutrition assistance and digestive enzyme supplementation is hugely important for pancreatitis patients.

Liver and gallbladder diseases

The pancreas isn’t the only player when it comes to digesting fats. In order to be absorbed from the intestines into the bloodstream, the fat molecules are encased in a substance called bile. Bile is produced by the liver and stored in the gallbladder, so diseases affecting either organ can affect the way a body is able to use fat.

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Congenital defects

Fat absorption isn’t relegated to one organ or process. As you can see from the varied list of diseases above, there are so many ways digestion can be disrupted. It doesn’t have to be caused by illness, either. A congenital defect that a person is born with in almost any organ can affect how the body can use essential nutrients, including fat. Defects in the intestines, where nutrients are broken down and absorbed, are of primary concern. The same goes for defects in the pancreas, liver and gallbladder, which are important when it comes to the enzymes and bile that are essential to the fat digestion process.

What You Need to Know About Fat Digestion and Digestive Enzymes - Specialty Enzymes & Probiotics™ (3)

Genetic diseases

There are uncommon hereditary diseases that in some way limit fat digestion. Whether they affect the digestive system directly, the nervous system or another area of the body entirely, researchers have made conclusive connections between these conditions and nutrient absorption. These genetic diseases include:

  • Gaucher disease
  • Tay-Sachs disease
  • Abetalipoproteinemia

Rare diseases

Scientists and doctors are continually learning more about diseases they don’t see frequently. Some are more prevalent outside of the United States, while others are common in certain climates or areas of the world. These rare diseases include:

  • Whipple disease
  • Tropical sprue
  • Short bowel syndrome

Medications and Treatments That Could Affect Fat Digestion

It’s not just your body that can throw off your fat digestion. The meds you take to heal your body and offset symptoms of other illnesses can negatively affect your nutrient absorption, too.

What You Need to Know About Fat Digestion and Digestive Enzymes - Specialty Enzymes & Probiotics™ (4)

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Extended use of antibiotics

Antibiotics are at the top of the list. Even a single course of antibiotics can throw off your digestive system, though it takes long-term use to cause enough malabsorption. Not only do antibiotics get rid of the bad bacteria present in your gut, but they also destroy the good bacteria necessary to help with digestion.Probiotics can help restore your gut floraafter occasional antibiotic use, while a digestive enzyme supplement can help with fat digestion and keeping your digestive system on track.

Radiation therapy

For people fighting cancer, radiation therapy has become a go-to treatment. It’s a lifesaver, but it can also cause other health problems. Among these problems are damage to the intestines and nutrient malabsorption.

How Digestive Enzymes Help Your Body Digest Fats

There are dozens of ways your body’s fat digestion can be thrown off course. The digestive system is complex. It withstands a lot—just think about all the different types of foods and drinks you can throw its way with nary a problem! However, it’s not all-powerful.

What You Need to Know About Fat Digestion and Digestive Enzymes - Specialty Enzymes & Probiotics™ (5)Digestive enzymes are proteins that break down the foodyou eat into essential nutrients that your body can use. The more help your body is given during the process of digestion, the easier it is for it to absorb and use these nutrients—and, in some cases, help you look and feel better and heal more quickly. From congenital defects to chronic diseases to medications used to treat other illnesses, there are so many things that can throw a wrench into the way your GI tract works and how successfully it’s able to digest the food you eat. Many of these wrenches impair your body’s ability to produce the quantity of digestive enzymes you need to break down the food you eat and absorb its nutrients. When your body isn’t producing enough of these enzymes on its own, a digestive enzyme supplement can be added to your daily nutrition plan to help boost your nutrient absorption. There are different enzymes that break down different types of food. If you’re having trouble digesting fats, for example, adding a supplement that includes the digestive enzyme lipase will help improve fat digestion and nutrient absorption.

What to Do if You’re Having Trouble Digesting Fats

Malnutrition and malabsorption show up in the way you look and feel every day. Even if you’re just feeling a little “off,” you should make an appointment to talk to your general practitioner, a gastroenterologist or a specialist you’re seeing already to manage a chronic condition. The faster you combat digestion problems, the more quickly you can solve them without doing your body any long-term damage. Your fix could be as simple asadding a digestive enzyme supplementto your diet. Talk to your doctor before you make a change. A nutritionist can also help get your digestive system back on track.


What to expect when you start taking digestive enzymes? ›

When starting enzymes, the body may experience what we like to call “adjustment effects” rather than true side effects. Many of the uncomfortable reactions such as an upset stomach, allergy-like symptoms or irritability are actually signs that the enzymes are working.

What should I look for when buying digestive enzymes? ›

Quality – To ensure that you are only taking the best digestive enzymes, look for supplements that are vegan, non-GMO, and include all-natural ingredients. You can also look for ones that are backed by clinical research, formulated by doctors and nutritionists, and that are third-party lab tested for quality.

When should I take probiotics and digestive enzymes? ›

The best time to take probiotics is on an empty stomach. Many people prefer to take them before breakfast in the morning or before going to bed at night. Digestive enzymes however function best when taken with meals.

Is there a downside to taking digestive enzymes? ›

Digestive enzyme supplements also could interact with antacids and certain diabetes medications. They may cause side effects including abdominal pain, gas and diarrhea.

Should you take digestive enzymes everyday? ›

“Overall, a healthy person really doesn't need to take digestive enzyme supplements,” Denhard explains. “The best digestive enzymes are the ones our bodies make naturally, and they work best when you eat a whole food diet.”

Can digestive enzymes help weight loss? ›

The benefits, although usually left somewhat vague, generally involve weight loss, more vitality, and a generalized sense of well-being. But will digestive enzymes actually help you lose weight? Actually, no they won't.

When should you take digestive enzymes morning or night? ›

When is the best time to take enzymes? For digestive purposes, it's best to take enzymes near the beginning of the meal. The goal is to maximize the amount of time the enzymes have in contact with the food.

How long does it take for digestive enzymes to start working? ›

As mentioned, it takes about ten minutes for digestive enzymes to reach the stomach and start working.

Should you take probiotics at night or in the morning? ›

The ideal time to take probiotics is right before bed because "the gut is pretty inactive at night. If you think about it, you don't usually wake up in the middle of the night to poop,” says Patricia Raymond, MD, a board-certified doctor in both gastroenterology and internal medicine.

When should you take probiotics morning or night? ›

Research shows the best time to take a probiotic is first thing in the morning before eating breakfast or before going to sleep at night. Probiotics are most effective when taken on an empty stomach.

What happens when you stop taking digestive enzymes? ›

Without them, your body can't break foods down so that nutrients can be fully absorbed. A lack of digestive enzymes can lead to a variety of gastrointestinal (GI) symptoms. It can also leave you malnourished, even if you eat a nutritious diet.

How many times a day should you take digestive enzymes? ›

What Are Dosages of Digestive Enzymes? Adults: 500 lipase units/kg per meal initially (up to the maximum dose); half the prescribed dose is given for an individualized full meal often administered with each snack; total daily dose should reflect approximately 3 meals plus 2 or 3 snacks/day.

How do I know if I need to take digestive enzymes? ›

Symptoms of enzyme deficiency tend to first show up in the gut. That's why you typically see digestive issues with insufficient enzyme levels like bloating, gas, diarrhea, constipation, and undigested food in stools. If your body doesn't have enough digestive enzymes, it's unable to break down foods properly.

Who should take digestive enzymes? ›

Taking digestive enzyme supplements is currently recommended for people with specific digestive disorders, such as pancreatic insufficiency and lactose intolerance.
Some side effects that people taking digestive enzyme supplements experience include:
  • Allergic reactions.
  • Interactions with medications.
  • Abdominal pain.
8 Dec 2021

Do digestive enzymes heal the gut? ›

There are a few diseases that affect enzyme production, but one of the biggest causes of enzyme deficiency is Leaky Gut Syndrome (LGS). This is ironic, because enzyme therapy is also crucial to heal leaky gut. Depending on your situation, your healthcare practitioner may suggest the use of digestive enzymes.

Can digestive enzymes affect poop? ›

The most common side effects of digestive enzyme supplements include constipation, nausea, cramps, and diarrhea.

Does probiotic enzymes help lose weight? ›

Probiotics are necessary for your body to break down food and support a healthy immune system. They may also promote weight loss.

What enzyme helps burn fat? ›

Lipase. Lipase supplements for weight loss may be useful, as lipase can help to increase the amount of fat that your body metabolizes.

How long should you wait to eat after taking enzymes? ›

All digestive enzymes should be taken 15-20 minutes before you eat.

How do you feel after taking digestive enzymes? ›

Side effects of taking digestive enzymes can include:

Upset stomach, stomach pains and cramping. Diarrhea. Nausea. Gas and bloating.

When should you not take probiotics? ›

In people with compromised immune systems, including those with HIV, AIDS, and several other conditions, probiotics can lead to dangerous infections (76). If you have a medical condition, consult your healthcare provider before taking a probiotic supplement.

Can you take digestive enzymes right after eating? ›

Enzymes Should be Taken with Food

That means, in most cases, you should take digestive enzyme supplements along with food. In many instances, they should be taken in combination with specific foods in order to properly perform their intended function.

What are the signs that probiotics are working? ›

But there are some common indicators that they may be working for you.
  • Less stomach pain. For some people, certain probiotics can help with stomach pain and cramps. ...
  • More frequent poops. ...
  • Less bloating. ...
  • Improved sleep. ...
  • Better mood, memory, and mental clarity. ...
  • Fewer vaginal infections.
20 Jul 2022

Can you drink coffee with probiotics? ›

So, the simple answer is that no, you don't need to worry about taking probiotics at the same time as you are enjoying your morning coffee, though ideally, I would swallow your probiotic supplement with a sip of water, in between sips of the delicious brown stuff (or any other hot drink you like to imbibe at breakfast- ...

What happens to your body when you start taking probiotics? ›

When you start taking a probiotic supplement, you introduce good bacteria into your gut. This may lead to a number of benefits such as healthy digestion and regularity, plus less bloating and gas, which means more abdominal comfort.

What happens when you stop taking probiotics? ›

When probiotics administration is suspended, the probiotic cells are rapidly released, resulting in dysbiosis of the gut microbiome and disruption of the intestinal metabolites and physical function.

Can I take vitamin D and probiotics together? ›

In addition, probiotics might have synergistic effects with vitamin D, through improving the expression of vitamin D receptors [9]. Therefore, modulating the microbiota-gut-brain axis by probiotics plus improving vitamin D levels might provide a novel target to treat mental and metabolic disorders.

Should probiotics be refrigerated? ›

Many probiotic bacteria are naturally sensitive to heat and moisture. Heat can kill organisms and moisture can activate them within pills, only to die due to lack of nutrients and a proper environment. These products should ideally be refrigerated and kept out of humidity.

Do digestive enzymes work immediately? ›

Digestion starts when we look at/think about food. If we need to use digestive enzymes, those enzymes need to be ready to go just before we eat. All digestive enzymes should be taken 15-20 minutes before you eat.

Can taking digestive enzymes help you lose weight? ›

The benefits, although usually left somewhat vague, generally involve weight loss, more vitality, and a generalized sense of well-being. But will digestive enzymes actually help you lose weight? Actually, no they won't.

Do digestive enzymes change your poop? ›

Enzymes don't affect gut motility. They can affect the size of the stools and this may be what most are actually seeing. Enzymes, at some dose, will break foods down more thoroughly such that more of the food is absorbed into the body and not passed out as feces.

How long does it take for digestive enzymes and probiotics to work? ›

The short answer: It takes most people 2 to 3 weeks to feel significant benefits when they start taking probiotics. That's because probiotics need time to accomplish their three key goals: increase your good bacteria count, decrease your bad bacteria count, and reduce inflammation.


1. Digestion vs. Absorption | How to Eat Healthy | Probiotics for Immunity Boost
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2. The Value of Digestive Enzyme Supplements
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3. Prebiotics & probiotics
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6. AIHM Wellness Webinar | Dr. Datis Kharrazian, PhD, DHSc, DC - Managing Gastrointestinal Disorders
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